Ingredients and Research

QUICK FACTS:
Forskolin is a plant extract that comes from the
Indian Coleus plant (Plectranthus Barbatus)

Forskolin is clinically proven to aid with weight loss. It also regulates blood pressure, can assist with nerve repair, and provide antibiotic and anti-inflammatory effects - making it a very powerful 'life extension' plant extract.

Studied benefits of Forskolin:

  • Weight loss aid
  • Blood pressure regulator
  • Nerve repair in Parkinsons and dementia
  • Antibiotic properties
  • Anti-inflammatory properties
To date, there have been more than two clinical studies examining the effectiveness of forskolin as a weight loss aid.

Various experimental studies are underway in using Forskolin in treatment for diseases such as Parkinsons - and for nerve damage caused by trauma or accident.

Forskolin can be used to promote nerve repair by increasing concentrations of nerve messengers in the brain, known as cAMP.

The research on this, in relation to cognitive deficits in age-related illnesses, is of particular interest to researchers studying the brain.

Functions as an antibiotic to prevent urinary tract and bladder infections (Source: 2007 clinical study lead by Pathologist Soman Abraham of the Duke University Medical Center in Durham, North Carolina)

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QUICK FACTS:

Astaxanthin can be found in krill and ocean algae -
and is the strongest anti-oxidant found in nature

Astaxanthin (pronounced "asta-santeen") has been shown in multiple clinical studies to have serious positive effects on human health. Most of the foods we eat do not contain enough astaxanthin - so a daily dietary supplement is required to consume the recommended daily value.

Studied benefits of Astaxanthin:

  • Believed to inhibit certain forms of cancer
  • Strengthening of the immune system
  • Proven heart and cardiovascular benefits
  • An anti-oxidant even stronger than beta- carotene and Vitamin E
  • Has an anti-aging effect on human cells through strengthening of cell membranes
  • Biologically available directly to the brain and nervous system - reducing the risk of diseases such as glaucoma and Alzheimer's
  • The ability to reduce inflammation in the body

In medical terms - astaxanthin Inhibits "lipid peroxidation" at the cell level, thus protecting the cell membrane.

It also provides significantly more antioxidant capacity than other carotenoids and antioxidants such as beta-carotene and Vitamin E.

 

Astaxanthin very likely increases cell gap junctional communication, a mechanism thought to inhibit cancer.

Neutralizes singlet and triplet oxygen (de-charges) generated by UVA and UVB radiation and other sources.

It increases immune system functioning, including heightened production of antibody-secreting cells and 'Interleukin 2'. Through this process - it effectivel limits reactive oxygen species that cause several types of inflammation.

Astaxanthin crosses the so-called "blood/brain barrier", which means it is made more available to the eye, brain and central nervous system to alleviate oxidative stressthat contributes to vision- and neurodegenerative diseases such as Glaucoma and Alzheimers.

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QUICK FACTS:

Resveratrol is a plant compound found in red grapes, red wine, and cocoa powder.

Resveratrol has been studied heavily for its life extension properties, anti-inflammatory effects, weight loss benefits, and more. Among other things, it can help protect the nerve- and cardiovascular systems in the body to strengthen

Studied benefits of Resveratrol:

  • Increase fat cell metabolism
  • Strengthening of the immune system
  • Strengthening of the heart and cardiovascular system
  • Anti-inflammatory effects for treating arthritic pain and discomfort
  • Anti-diabetic effects - regulating blood sugar levels in type I and II diabetes

Resveratrol may help increase fat metabolism:
"The researchers note that resveratrol has been shown to activate molecules that are also important in fat metabolism in the liver."
SOURCE: Study conducted by University of Florida. Published in The American Journal of Physiology-Gastrointestinal and Liver Physiology.

Neuroprotective effects: In humans, oral doses of resveratrol may reduce plaque formation in the brain (typically associated with dementia and Alzheimers)

Antidiabetic effects: In human clinical trials, resveratrol has lowered blood sugar levels in studies conducted by Sirtris Pharmaceuticals.

Antiviral effects: Studies show resveratrol inhibits

Similar studies have shown that resveratrolinhibits the herpes simplex virus (HSV) types 1 and 2, varicella-zoster virus, certain influenza viruses, respiratory viruses, and human cytomegalovirus.

Furthermore, resveratrol synergistically enhances the anti-HIV-1 activity of several anti-HIV drugs.

Cardioprotective effects: Moderate drinking of red wine has long been known to reduce the risk of heart disease. Studies suggest resveratrol in red wine may play an important role in this phenomenon.
“Our data demonstrate that both melatonin and resveratrol, as found in red wine, protect the heart in an experimental model of myocardial infarction via the SAFE pathway.”
SOURCE: Study published on PubMed.gov, 2011 by Lamont KT, Somers S, Lacerda L, Opie LH, Lecour.

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QUICK FACTS:
CoQ10
is an enzyme that is found naturally in
all of the cells of the human body.

  

CoQ10 exists in all of our cells, and is also one of the most powerful anti-oxidants in our bodies. Our regular CoQ10 levels get lower as we age (it does not regenerate itself) - and can only be maintained through dietary supplementation.

Studied benefits of CoQ10:

  • Restores a normal cholesterol level
  • Acs as a natural blood pressure regulator, and can decrease high blood pressure (hypertension)
  • Improvement in immune function in people with HIV or AIDS
  • Increase sperm motility, improving male fertility
  • Usage of the treatment for Parkinson's disease
  • Improve exercise ability in people with angina
  • Prevention of frequent migraines

 

Results of the first placebo-controlled, multicenter clinical trial of the compound CoQ10 suggest that it can slow disease progression in patients with early-stage Parkinson's disease. While the results must be confirmed in a larger study, they provide hope that this compound may ultimately provide a new way of treating Parkinson's disease.

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SOURCES: National Institute of Neurological Disorders and Stroke, Coenzyme Q-10 and Lifespan Extension - Advances in Anti-Aging Medicine, Mechanisms of Ageing and Development, Experimental Gerontology, Effects of Coenzyme Q10 in Early Parkinson Disease - Evidence of Slowing of the Functional Decline - Archives of Neurology



QUICK FACTS:
Curcumin is a plant extract that comes from the Turmeric plant (Curcuma Longa)

Curcumin has been a major part of Indian and Middle-Eastern diets for over a thousand years. In these countries, the curcumin plant extract is frequently used as a spice, coloring, or additive in home cooked foods and restaurants.

In fact, there is substantial evidence pointing to the vital role curcumin may play in the diets of countries like India. For instance, some of the most common causes of death in the U.S. and Europe (where curcumin is not part of a regular diet) are cancers, and neurological diseases such as Alzheimers and Parkinsons.

curcumin cancer prevention

In the US, the death rate from Parkinsons disease is 11 (eleven!) times higher than that of India. On top of that, the death rate from Alzheimers is 8 (eight!) times higher in the US than in India.

Additionally - 5.5 times more people die from lung cancer compared to India, and the death rate is 4 to 4.5 times higher in the US for diseases like colon cancer and prostate cancer, respectively.

SOURCE: 2012 Statistics, Worldlifeexpectancy.com

Studied benefits of Curcumin:

  • Functions as an anti-oxidant
  • Has inflammatory properties
  • Showing promise in research on cancer prevention and treatment
  • Possible preventive and treatment possibilites for diseases such as Alzheimer's
  • Slow down disease in the liver
  • Can correct defects in humans with cystic fibrosis

In both in vitro and animal studies, curcumin has shown anti-tumor, antioxidant, anti-arthritic, and anti-inflammatory properties.

Cancer prevention studies: Its potential anti-cancer effects stem from its ability to induce cell death in cancerous cells - without harmful effects on surrounding healthy cells. Curcumin can interfere with the activity of the protein "NF-κB", which has been linked to a number of inflammatory diseases such as cancer.

An in vitro study reported that curcumin effectively inhibits tumor cell proliferation, as well as migration and invasion. Additionally - curcumin has been shown in other vitro studies that it might contribute to activity against breast cancer.

Neuroprotective effects: The effect of curcumin on so-called "amyloid beta" plaque build up (a major cause for Alzheimers) has been the focus of several studies.

"We hope that Vitamin D3 and curcumin, both naturally occurring nutrients, may offer newpreventive and treatment possibilities for Alzheimer's disease" said Dr. Milan Fiala, study author and a researcher at the David Geffen School of Medicine at UCLA and the Veterans Affairs Greater Los Angeles Healthcare System.

Scientists at the Cork Cancer Research Centre in Ireland treated oesophageal cancer cells with curcumin. Among the findings were that curcumin started to kill cancer cells within 24 hours.

Heart and cardiovascular health: Curcumin promotes cardiac health and repair through multiple different mechanisms.

A study found that curcumin might be potentially useful in some kidney diseases byreducing inflammation.

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SOURCES: Annals of the New York Academy of Sciences, The Journal of Alternative and Complementary Medicine, Biological and Pharmaceutical Bulletin, Wikipedia, Neurochemical Research, Molecular Pharmacology, Biochemical Pharmacology, BMC Cancer, Cell Physiology and Biochemistry.



QUICK FACTS:
Vitamin D3 is a nutrient found in some foods - and can also be generated by our bodies when our skin is exposed to enough sunlight

Vitamin D3 is gaining more and more interest from doctors and scientists who are doing research on cancer and heart disease. This vitamin can be found in certain foods, and can also be generated from sunlight. However - most people do not get a sufficient amount of Vitamin D3 to take full advantage of its widely renowned benefits.

Most of the food we eat simply does not have enough Vitamin D3. For instance, you can get 425 IU in a 3-ounce serving of salmon, and 270 IU in 3.5 ounces of canned sardines. But most foods provide much more modest amounts of vitamin D, from egg yolks (25 IU per egg) to cheddar cheese (2.8 IU per ounce). Source: WebMD.

curcumin cancer prevention

Levean contains 8000 IU of Vitamin D3, more than most nutritional supplements out there.

 

Studied benefits of Vitamin D3:

  • Reduces high blood pressure
  • Regulates the immune system
  • Stimulates insulin release
  • Reduces arthritic inflammation
  • Reduces the risk of diabetes
  • Showing promise in research on cancer prevention and treatment - particularly cancers of the breasts, colon, ovaries, esophagus, and lymphatic system.

A study in the Jan. 13, 2004 issue ofNeurology indicated that women who get doses of vitamin D of at least 400 IU - are40% less likely to develop MS (Multiple Sclerosis) compared with those not taking Vitamin D supplements.

If you want to lower your blood pressure, trying to reduce your risk of diabetes, or lower your chances of heart attacks, rheumatoid arthritis, or multiple sclerosis, then vitamin D should be at the front of the line in your daily supplement regimen.Source: WebMD.

"Vitamin D is one of the most potent inhibitors of cancer cell growth. It also stimulates your pancreas to make insulin. It regulates your immune system." - Michael F. Holick, PhD/MD, head of Vitamin D Research Laboratory at Boston University School of Medicine.

People who get too little vitamin D may develop soft, thin, and brittle bones, a condition known as rickets in children and osteomalacia in adults.Source: National Institute of Health

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QUICK FACTS:
Chromium Picolinate is an essential trace mineral that exists in certain foods such as oysters, brewer's yeast, and whole grains.

Chromium's presence in these foods however, is limited by significant food processing methods - and the average American dietary intake of Chromium is often insufficient.

Studied benefits of Chromium:

  • Potential ability to regulate blood sugar levels and insulin sensitivity
  • Lowering blood pressure. Several studies Lowers LDL - “bad” Cholesterol, and elevates HDL – the “good” Cholesterol and in effect may contribute to reduce the risk for heart attack or stroke.

Chromium picolinate in contrast to other chromium salts is better absorbed during digestion leading to a higher chromium blood level and is therefore more often preferred than other chromium supplements.

Chromium may have a positive effect on eye health.There is a link between low chromium levels and increased risk of glaucoma.

Chromium may help control diabetes and symptoms related to high blood sugar. In people with type 2 diabetes, the pancreas secretes plenty of insulin in an effort to regulate blood sugar levels, but the body's cells don't respond to it.

Researchers have found that a molecule called ''glucose tolerance factor'' (GTF) is critical for increasing the sensitivity of these cells to insulin. Since GTF contains chromium, and it does indeed increase insulin sensitivity, chromium supplements may have a role to play in normalizing blood sugar levels.

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